Abstract
A study was made of the reaction and reconstructive regeneration of the insular tissue of albino rat pancreas with administration of low alloxan doses (five subcutaneous injections of 5% aqueous solution of alloxan −5 mg per 100 g body weight). Preliminary short-term administration of a low alloxan dose caused no destructive changes in the insular tissue of partially pancreatectomized animals; it activated the secretory function of the beta-cells, leading to the formation of new islets by transforming the acinar tissue into isletins.
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