Abstract
BackgroundTo investigate the ameliorating effect of sitagliptin, a dipeptidyl peptidase-4 inhibitor, on blood glucose control in patients with type 2 diabetes mellitus who were previously untreated with or who have a poor responsive to existing antidiabetic drugs.MethodsSitagliptin (50 mg/day) was added on to the pre-existing therapy for type 2 diabetes and changes in the glycated hemoglobin (HbA1c) level after 3 months of treatment were compared with the baseline and performed exploratory analysis.ResultsHbA1c levels were significantly decreased after 1 month of treatment compared to baseline, with a mean change in HbA1c level from baseline of −0.73% (range, −0.80 to −0.67) in the entire study population at 3 months. Patients who received a medium dose of glimepiride showed the least improvement in HbA1c levels. The percentage of patients who achieved an HbA1c level of <7.0% significantly increased after 1 month of treatment, reaching 53.1% at 3 months. The percentage of patients who achieved a fasting blood glucose level of <130 mg/dL significantly increased after 1 month of treatment, reaching 50.9% at 3 months.ConclusionsSitagliptin improved the HbA1c level and rate of achieving the target control levels in patients with type 2 diabetes mellitus who were previously untreated with, or poorly responsive to, existing antidiabetic drugs. Thus, sitagliptin is expected to be useful in this patient group. However, the additional administration of sitagliptin in patients treated with medium-dose glimepiride only slightly improved blood glucose control when corrected for baseline HbA1c level.Electronic supplementary materialThe online version of this article (doi:10.1186/s12902-016-0149-z) contains supplementary material, which is available to authorized users.
Highlights
To investigate the ameliorating effect of sitagliptin, a dipeptidyl peptidase-4 inhibitor, on blood glucose control in patients with type 2 diabetes mellitus who were previously untreated with or who have a poor responsive to existing antidiabetic drugs
The 2012 National Health and Nutrition Survey conducted by the Ministry of Health, Labour and Welfare of Japan (MHLW) estimated that approximately 20.5 million people were strongly suspected of having diabetes mellitus; these patients are considered the at-risk group of individuals in whom diabetes mellitus cannot be ruled out [1]
There were 22 (3.4%) participants at 3 months and 37 (5.7%) participants at 12 months reported as poor adherence of sitagliptin
Summary
To investigate the ameliorating effect of sitagliptin, a dipeptidyl peptidase-4 inhibitor, on blood glucose control in patients with type 2 diabetes mellitus who were previously untreated with or who have a poor responsive to existing antidiabetic drugs. Many reports of sitagliptin had published, but we have examined the additional effect of sitagliptin in 7 pre-existing therapy groups. Treatment of these patients often includes other antidiabetic medications because they often have diverse complications. The objective of this study is to investigate the ameliorating effect of sitagliptin on blood glucose control in patients with type 2 diabetes mellitus, who were previously untreated with, or who had a poor responsive to, existing antidiabetic drugs
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