Abstract
Histone deacetylase 1(sirtuin 1, SIRT1)is an important member of deacetylase family, and plays an important role in the process of malignant tumor and embryonic development. In this article it was found that overexpression of SIRT1 could accelerate the DNA synthesis in human pancreatic beta cell CRL-1837 and inhibit cell senescence. SIRT1 also could bind to p53 as detected by co-immunoprecipitation and could change the phosphorylation level of p53. Key words: Sirtuin; Pancreatic β-cells; Proliferation; Senescence; Tumor suppressor gene p53
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