Abstract
The effect of a single oral dose of DDT (150 mg/kg body wt) on the lipid metabolism of rhesus monkey has been investigated 48 hr after the administration of the drug. There was hypertriglyceridemia and increased triglyceride levels in adipose tissues of experimental animals. The increased triglyceride levels in plasma seemed to be due to their increased mobilization from the liver and decreased removal rate from plasma. However, postheparin plasma lipolytic activity (PHLA) of both protamine-sensitive and -resistant types increased in the plasma. Further, there was increased lecithin-cholesterol acyltransferase (LCAT) activity in DDT-treated animals which contributed to the increased esterified cholesterol in plasma. There was increased conversion of [ 14C] glucose into hepatic triglyceride but the lipid content did not change significantly in the tissue possibly due to the increased lipolytic activity and secretion into plasma.
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