Abstract
(1) Background: Regular exercise induces physiological and morphological changes in the organisms, but excessive training loads may induce damage and impair recovery or muscle growth. The purpose of the study was to evaluate the impact of Silymarin (SM) consumption on endurance capacity, muscle/cardiac histological changes, bodyweight, and food intake in rats subjected to 60 min of regular exercise training (RET) five days per week. (2) Methods: Male Wistar rats were subjected to an eight-week RET treadmill program and were previously administered SM and vitamin C. Bodyweight and food consumption were measured and registered. The maximal endurance capacity (MEC) test was performed at weeks one and eight. After the last training session, the animals were sacrificed, and samples of quadriceps/gastrocnemius and cardiac tissue were obtained and process for histological analyzes. (3) Results: SM consumption improved muscle recovery, inflammation, and damaged tissue, and promoted hypertrophy, vascularization, and muscle fiber shape/appearance. MEC increased after eight weeks of RET in all trained groups; moreover, the SM-treated group was enhanced more than the group with vitamin C. There were no significant changes in bodyweight and in food and nutrient consumption along the study. (5) Conclusion: SM supplementation may enhance physical performance, recovery, and muscle hypertrophy during the eight-week RET program.
Highlights
Exercise training induces a wide variety of modifications within organs and systems, and Exercise training induces a wide variety of modifications within organs and systems, and skeletal skeletal muscle and cardiac tissue engage in dynamic crosstalk regarding the mediation of muscle and cardiac tissue engage in dynamic crosstalk regarding the mediation of adaptations during adaptations during physical exercise
We evaluate the impact of SM consumption on bodyweight, food/nutrient consumption, and on the physical capacity of the muscle and myocardium histological modifications in a rodent model subjected to regular exercise training
Analysis among the groups indicates a significant difference between exercise training group (ET) and ET + VC vs. control group (CON) (p = 0.019), but there was no difference with the ET + SM group (p = 0.841)
Summary
Exercise training induces a wide variety of modifications within organs and systems, and Exercise training induces a wide variety of modifications within organs and systems, and skeletal skeletal muscle and cardiac tissue engage in dynamic crosstalk regarding the mediation of muscle and cardiac tissue engage in dynamic crosstalk regarding the mediation of adaptations during adaptations during physical exercise. The two basic skeletal muscle functions comprise providing physical exercise. The two basic skeletal muscle functions comprise providing stability for body stability for body posture and contraction for body movement. The skeletal muscle mass comprises posture and contraction for body movement. The skeletal muscle mass comprises around 50–75% of around 50–75% of the body protein pool and 40–50% of bodyweight [1]. Muscle is able to adjust to the body protein pool and 40–50% of bodyweight [1]. Muscle is able to adjust to different amounts different amounts of tension when the workload increases and mechanical stress rises; it adapts of tension when the workload increases and mechanical stress rises; it adapts by producing by producing more contractile proteins along with an increase in muscle fiber size and a consequent more contractile proteins along with an increase in muscle fiber size and a consequent force power [2]
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