Abstract
Background: Exercise training induces adaptive physiological and morphological modifications in the entire organism; however, excessive loads of training may increase damage in tissues. The purpose of this study was to evaluate the effect of silymarin in lung and liver histological changes in rats subjected to exercise training (ET). Methods: Male Wistar rats were subjected to an 8-week ET treadmill program 5 days per week, 60 min/session, and were previously administered 100 mg ascorbic acid or 100 mg of silymarin. Results: Silymarin increased alveolar and bronchial muscle size, improve vascularization, and reduced tissue inflammation. In liver, silymarin promoted the reduction of lipid content. Conclusion: Silymarin supplementation may improve inflammation in pulmonary tissue after 8 weeks of the ET treadmill program, improve cell recovery, and reduce intrahepatic lipid content.
Highlights
Type 2 pneumocytes increased to moderate size in the exercise training (ET)+Aa and in exercise-training and silymarin group group (ET+Sm) groups compared to the low level reported in the ET
A moderate increase was observed in the thickness of pleural tissue in the ET group, while in the groups administered with ascorbic acid and silymarin, this thickness remained low
Higher hypertrophy of the bronchial muscle was observed in the group treated with silymarin than in the ET and exercise-training and ascorbic acid group (ET+Aa) groups
Summary
The practice of physical exercise is responsible for inducing a variety of modifications in the whole organism as a result of adaptation. The capacity of the organism to cope with high demands depends on the equilibrium between the level of the exercise-induced damage and the endogenous and exogenous defense systems [3]. Exercise training induces adaptive physiological and morphological modifications in the entire organism; excessive loads of training may increase damage in tissues. The purpose of this study was to evaluate the effect of silymarin in lung and liver histological changes in rats subjected to exercise training (ET). Results: Silymarin increased alveolar and bronchial muscle size, improve vascularization, and reduced tissue inflammation. Conclusion: Silymarin supplementation may improve inflammation in pulmonary tissue after 8 weeks of the ET treadmill program, improve cell recovery, and reduce intrahepatic lipid content
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