Effect of Sieve Size for wet and Dry Screening on the Physical Properties of Lactose Granules and Their Corresponding Tablets

Abstract

AbstractVarious batches of lactose granules were prepared by wet granulation process using acacia, cassava starch and polyvinylpyrrolidone separately as binders by inter-changing sieves for wet and dry screening, The effects of wet and dry screen aperture sizes together with the effects of the binders used on the physical properties of such granules and the corresponding tablets were investigated. The bulk volume of granules was found to be increased as the aperture size of sieves for dry screening increased while keeping a particular sieve constant for wet screening. No significant difference was observed with regards to the effect of sieve size upon the flow rate.It was also observed that keeping the sieve size for wet screening constant, the mean tablet weight increased while the tablet weight variation decreased as the sieve size for dry screening decreased. There found to be an observable relationship between the sieve sizes used for dry and wet screening, average granule size and hardness of tablets...