Abstract
The effect of a shift of the blood O 2 dissociation curve (ODC)_on the alveolar-arterial O 2 gradient was studied in computer models of the lung with several degrees of V̇ a/Q̇ inequality during air breathing. A shift to the left decreases and a shift to the right increases not only the mixed-venous but also the arterial P O 2 . Consequently the alveolar-arterial O 2 gradient is larger with a left with a left and smaller with a right shift of the ODC. This effect of a shift of the ODC on the alveolar-arterial O 2 gradient is negligible in a healthy lung but becomes quite considerable in a diseased lung with a severe mismatching of V̇ a/Q̇.
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