Abstract
Objective To evaluate the effect of sevoflurane preconditioning on autophagy in the operated lung tissues of the patients undergoing one-lung ventilation. Methods Forty patients of both sexes, with American Society of Anesthesiologists physical status Ⅰ-Ⅲ, aged 30-80 yr, weighing 45-84 kg, scheduled for elective radical operation for lung cancer performed via video-assisted thoracoscope under general anesthesia, were divided into control group(C group)and sevoflurane preconditioning group(SP group), with 20 patients in each group.In SP group, sevoflurane was inhaled for 30 min with the final concentration of 2.0%, followed by washout.The normal lung tissues(the distance from the edge of the lump>2 cm)around the lump were obtained for detection of the expression of microtubule-associated protein 1 light chain 3 Ⅱ by Western blot. Results Compared with C group, the expression of microtubule-associated protein 1 light chain 3 Ⅱ in lung tissues was significantly up-regulated in SP group(P<0.05). Conclusion Sevoflurane preconditioning can enhance autophagy in the operated lung tissues of the patients undergoing one-lung ventilation, which may be related to the lung protective effect. Key words: Anesthetics, inhalation; Ischemic preconditioning; Autophagy; Respiration, artificial; Respiratory distress syndrome, adult
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callDisclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
