Abstract
ObjectiveThe hippocampal neuron electrophysiology and structure might be the basis of postoperative cognitive function‐related diseases after anesthesia. Here, we examined whether sevoflurane inhalation affected the electrophysiological and ultrastructural morphology of the hippocampal neurons.MethodsThe rats were randomly divided into the air/oxygen and Sevoflurane group (SEV group). The air/oxygen group inhaled carrier gas (1 L/min O2 + 1 L/min air) for 2 hours; The SEV group inhaled 3.4% sevoflurane & carrier gas for 2 hours. After that, the hippocampal electrophysiology signals were observed 1 week after anesthesia. Then, Transmission Electron Microscope was used to observe the neuron cell morphology, structures, and related synaptic morphology in hippocampi.ResultsCompared with the air/oxygen group, the numbers of spontaneous discharge and the values of maximum current significantly decreased in the SEV group, and the neuron cytoplasm edema and organelles also were damaged.ConclusionThe results showed that sevoflurane could weaken the electrophysiological signals of hippocampal neurons and damage the ultrastructure of neurons.
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