Abstract
The present experiments evaluated the effects of progressive, severe hypovolemia on heart rate (HR) and mean arterial blood pressure (MAP) in adult rats. HR and MAP were continuously monitored with telemetry. Subcutaneous injection of a 30% polyethylene glycol (PEG) solution was used to produce a volume loss of 4–5% per hour for 5–6 h, a rate that subsequently slowed with volume deficits asymptoting at ~40% during hours12–24 post‐injection. In all animals, MAP was stable at ~110 mm Hg throughout the 24‐h test period. In contrast, HR increased gradually by ~50 bpm during the first 4 h from basal values of 370–400 bpm, and then it fell by 150–200 bpm during the next 4 h before gradually rebounding during the next 12 h. These results allow the hypotheses that the initial tachycardia reflected excitation of the sympathoadrenal system, the subsequent fall in HR reflected an inhibition of the sympathetic nervous system associated with a large and sustained drop in plasma volume unrelated to changes in MAP, and the later restoration of HR reflected a return of sympathetic activity when the rate of volume loss slowed. Similar to these findings, previous studies have shown that bradycardia follows tachycardia after severe hemorrhage; consequently, the present results suggest that this pattern results from the induced change in blood volume. Ongoing experiments are evaluating these hypotheses.
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Disclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.