Abstract
Nematospiroides dubius, a trichostrongyloid parasite of mice, was first described in detail by Baylis (1926, 1927). The life cycle of N. dubius was first determined by Spurlock (1943) and further elucidated by Ehrenford (1954a). Spurlock (1943), Ehrenford (1954b) and Baker (1954, 1955) have contributed information concerned with host-parasite relationships between N. dubius and laboratory mice. Although this parasite is of no economic or medical importance it has many characteristics that make it a desirable form for further study. It is easily maintained in mice. It is restricted to the intestinal tissues, thus making it possible to study the intestinal phase of host reactions to parastism separate from other tissues. It was the purpose of this study to elucidate factors affecting establishment and persistence of N. dubius in mice and to determine the effect of superinfection with N. dubius, Ancylostoma caninum or Trichinella spiralis on an initial N. dubius infection. These effects were measured by determining, after superinfection, (1) total egg production (2) egg production per female (3) worms remaining after superinfection (4) percentage of eggs developing normally after superinfection.
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