Abstract
Serotonin (5HT) is known to be one of the most active aldosterone-stimulating substances in rat adrenal tissue, but its effect in vivo has been scarcely investigated, especially in man. We have studied the effect of an infusion of 5HT in 14 normal subjects. Plasma aldosterone significantly increased during 5HT infusion, while Cortisol and plasma renin activity were not modified. No changes in serum K, blood pressure or heart rate were noticed. These data suggest that 5HT may influence aldosterone secretion also in man.
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