Abstract
Salvadora persica, Moringa pergrina and Citrullus colocynthis are three traditional important medicinal species used in indigenous medicinal herbal drugs to cure various diseases in South Asia and Middle East countries. The objective of the present study is to investigate the effects of oral administration of extracts of Salvadora persica leaves, Moringa pergrina leaves and Citrullus colocynthis seeds on different physiological parameters of mice. The leaves of Salvadora persica, Moringa pergrina and Citrullus colocynthis seeds were collected from Ibri and Al-Musanaa, dried and crushed into powder and extract was obtained by soxhalet apparatus. The extract was then administered to mice at a dosage of 0.5%, 1.0%, 1.5% and 2.0% for twenty one days. The mice treated with different concentrations of plant extracts showed different physiological changes, Salvadora persica leaf extract at 1.5% and 2.0% showed hypo activity, grooming, prostration, while mice treated with 0.5% and 1.0% showed no effective behavioral changes. The Moringa pergrina leaf extract dosage of 0.5%, 1.0%, 1.5% and 2.0% produced significant weight loss and affected the blood sugar level. Citrullus colocynthis seed extract at 1.5% and 2.0% showed abnormal sperms shape like circular head, double head and double tails whereas at 0.5% and 1.0% exhibited normal sperm shape.
Highlights
Medicine is considered as one of the most important necessities to all of us
It was found that mice treated with 0.5% and 1.0% of Salvadora persica leaves and Moringa pergrina leaves and Citrullus colocynthis seeds extract showed no distinct behavioral changes, while those treated with 1.5% of the above mentioned extracts showed multiple behavioral changes including: hypoactive asthenia, grooming and react vigorously during the oral route administration just after 21 days
It is concluded that the three medicinal plants which are used widely for treatment of various disorders in Sultanate of Oman are found to be effective in body weight reduction and the control of blood sugar level
Summary
Medicine is considered as one of the most important necessities to all of us. It is derived from the Latin words medicina meaning “the art of healing”. There are different types of medicines among which herbal medicine comes from different types of plants and their parts used in hospitals to treat various diseases and disorders. F mentioned in 2006 in his article; “The Rise of Science in Medicine” is herbal medicine, called botanical medicine or phytomedicine. It refers to use of any plant’s seeds, berries, roots, leaves, bark, or flowers for medicinal purposes. Whole herbs contain many ingredients and it is likely that they work together to produce the desired medicinal effect [1]
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