Effect of Selective COX-2 Inhibitor on Conception Rate, Progesterone and PGFM Profile in Buffalo (Bubalus bubalis)

Abstract

Rajkumar, R., Singh, S.K., Agarwal, S.K., Mahmood, S. and Shankar, U. 2010. Effect of selective COX- 2 inhibitor on conception rate, progesterone and PGFM profile in buffalo (Bubalus bubalis). J. Appl. Anim. Res, 38: 209–212. To determine the effect of selective COX-2 inhibitor (Meloxicam) on conception rate, progesterone and 13, 14-dihydro-15-keto-prostaglandin F2α(PGFM) profile, buffaloes in estrus were inseminated and divided into two equal groups. Meloxicam was injected @ 0.5 mg/kg body weight in tramuscularly on d 13, 14 and 15 post-insemination to treatment group and normal saline into control group. Conception rate was higher (20%) in the meloxicam treated buffaloes. Serum progesterone concentration did not differ (P>0.05) between the two groups. However, it was higher (P<0.05) on day 18, 21 and 24 post-insemination in pregnant animals indicating maintenance of CL and thus pregnancy. The serum PGFM concentration was (P<0.01) lower on d 15 in meloxicam treated pregnant and non-pregnant buffaloes indicating decrease in PGF2α secretion following administration of a selective COX-2 inhibitor. The results demonstrated beneficial effect of selective COX-2 inhibitor on conception rate in buffalo.