Abstract
This study was carried out on the chemical extract of leaves of the plant of Al-Shinan and was aimed at the most important chemical components of plant leaves, and quantitative determination major phytochemicals then tested on laboratory animals to know the most effective dose in reducing the concentration of total cholesterol in the serum blood of experimental animals. The Chemical tests showed that the leaves contain alkaloids, clicosides, phenols, flavinoids, soap and tannins. On the other hand, the total value of the yield of the ethanolic extract was 18.92%. and the results also showed the extract contained 1.112% phenol, 0.393% flavonoids and 1.5225% soap. In order to extract the most effective dose of the extract of this study, thirty mature male rats were selected and divided into five equal groups. The first was considered as a control group and only the distilled water was administered and the other groups were given 100,200,300 and 400 mg of crude ethanol / kg body weight. For four weeks. After two and four weeks of treatment, the results of the total cholesterol concentration measurements of the animals' forbidden blood samples for more than eight hours showed that the 200 mg / kg B.W. dose caused the highest reduction in total cholesterol concentration.
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