Abstract
Sedatin, an analog of the opioid peptide dermorphin, which is a mixed μ- and δ-receptor agonist, had no effect on DNA synthesis and mitotic activity in the corneal or lingual epithelium of rats in a single dose 10 μg/kg, but stimulated cell division in both epithelia in a single dose of 100 μg/kg and in the 10 μg/kg dose administered either once daily over a 21-day period or just once after a single injection of the opiate receptor antagonist naloxone.
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