Abstract
Totally isolated whole canine stomachs, perfused ex vivo with homologous blood, were used for recording of myoelectrical and mechanical activity prior to and following the injection of secretin. Secretin was given as flash injections (0.5 - 32 U) or constant infusions (60 U/h). Background stimulation of stomachs was obtained by intragastric instillation of fluid, by the infusion of pentagastrin or bethanechol chloride, and by electrical stimulation of the Latarjet branch of the vagus nerve. Hormones were injected into the gastric arterial circulation. Secretin had no effect on the frequency of electrical control activity. Secretin inhibited electrical response activity when injected against the background of electrical vagus stimulation. Secretin also inhibited or decreased mechanical activity of the gastric antrum, recorded at the site of the antral strain gauge.
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callDisclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
