Abstract
Wan Wan Lin, C. Y. Lee and J. W. Burnett. Effect of sea nettle ( Chrysaora quinquecirrha) venom on isolated rat aorta. Toxicon 26, 1209–1212, 1988.—The venom from sea nettle ( Chrysaora quinquecirrha) (1–10μg/ml) produced an irreversible contraction of the isolated rat aortic ring that was slow in onset, increased with time, and reached maximum in about 10–20 min. The contraction was not inhibited by pretreatment with phenoxybenzamine, atropine, indomethacin, tetrodotoxin, ouabain, low Na + or Na +-free medium, however, it was markedly decreased by the Ca 2+ channel blockers, nifedipine and verapamil. In Ca 2+-free medium, no increase in tension was produced by the venom. It is concluded that sea nettle venom causes a contraction of the rat aortic ring by increasing Ca 2+ influx through the voltage-dependent Ca 2+ channels.
Sign-in/Register to access full text options 
Free) 
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a call
