Abstract
Scutellarin (SCU), a flavonoid from a traditional Chinese medicinal plant, is clinically used to treat cardiovascular diseases. In this study, we investigated the vasoprotective effects of SCU against hypoxia reoxygenation (HR) in isolated rat coronary artery (CA). HR treatment significantly impaired acetylcholine (ACh,0.001‐100 µM)‐induced endothelium‐dependent relaxation in isolated CA rings and these effects were reversed by pre‐incubation with SCU (500 µM). SCU pre‐incubation did not affect ACh response in normal CA without HR treatment. HR treatment did not significantly altered nitroglycerin (NTG, 0.001‐10 µM) induced endothelium‐independent vasodilation in CA and SCU (500 µM) had no significant effect on NTG response in CA with or without HR treatment. The PKG inhibitor Rp‐8‐Br‐cGMPS (4 µM) blocked both the vasorelaxative effects of SCU in CA rings without HR treatment and the vasoprotective effects of SCU in HR‐treated CA. These results demonstrate that SCU repairs HR‐induced vascular impairment in endothelium‐dependent vasodilation and might be via activation of the PKG pathway.Grant Funding Source: Supported by grants from the National Natural Science Foundation of China (Nos. 30960450 and 81173110) and Yunnan Provincial Science and Technology Department (Nos. 2011FA022, 2012BC012, 2008CD054, and 2008ZC111M).
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