Abstract
In an attempt to determine the effect of deafferentation upon central nervous system myelinogenesis, a right sciatic neurectomy was performed on newborn rats. The dorsal funiculus of the thoracic spinal cord was studied on subsequent days, and the results indicated definite deficiencies on the deafferented side which included fewer large axons and thinner myelin sheaths. Phase microscopic data are presented along with measurements of axon diameter and myelin sheath thickness. It is concluded from these experiments that physiologic activity in the nerve fiber is a significant factor affecting myelinogenesis, which exerts its effect through some mechanism other than axonal size alone.
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