Abstract
TETRODOTOXIN and saxitoxin are neurotoxins with very similar biological actions, though they are chemically distinct. Tetrodotoxin reduces the amplitude of the end plate potential elicited by neural stimulation. At the same time, however, the end plate membrane remains entirely responsive to acetylcholine1–3. Kao and Nishiyama4 found that the actions of saxitoxin on the neuromuscular system are similar to those of tetrodotoxin. The blockade of neuromuscular transmission by saxitoxin affects the motor axon and muscle membrane, while the end plate receptor is not affected.
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