Effect of savory and yarrow on spermatogenesis in adult mice undergoing chemotherapy Cyclosporine

Abstract

Spermatogenesis process during which the male germ cells are produced at each stage of the disorder, it can lead to infertility. The aim of this study was to evaluate the effect of fennel and yarrow on spermatogenesis in adult micereceiving chemotherapy is cyclosporine. For this study, 32 male Wistar rats with an average weight of 20 ± 200 g were randomly divided into four groups (control, cyclosporine A, cyclosporine and aqueous extracts of yarrow, cyclosporine and aqueous extract of fennel). Three groups of mice at a dose cyclosporine day / kg / mg40 dissolved in half ml sesame oil, received daily. The other two groups, water extracts of yarrow and fennel with a dose of day / kg / mg 150 received. After 21 and 45 days, all rats were euthanized, the testis and epididymis were separated in the next stage of sperm characteristics, morphological changes and morphological index were Trzya by spermatogenesis. Administration of cyclosporine A significant reduction in the number and motility of sperm, as well as a significant increase in the amount of dead and abnormal sperm has caused. If the plant extracts of yarrow and fennel is to improve these parameters. The results of this study show that cyclosporine A by oxidative stress can damage the testes provide, while the aqueous extract of yarrow and fennel with scavenging free radicals and oxidative processes can be reduced the adverse effects of this drug.