Abstract
Objective To investigate the effect of sarcopenia on the skeletal muscle and cardiac function in elderly patients with chronic heart failure (CHF). Methods Sixty patients with CHF and sarcopenia and 60 sex and age-matched CHF patients without sarcopenia were enrolled from September 2014 to December 2015. The skeletal mass was evaluated by fat-free mass index (FFMI) and muscle function was evaluated by gait speed (GS), hand strength (HS) and the simple physical performance battery (SPPB). The cardiac function was accessed by a 6-min walk distance (6-MWD) and left ventricular ejection fraction (LVEF). Furthermore, the serum inflammation cytokines IL-6, TNF-α, and skeletal muscle biomarker C1q were measured. Results The CHF patients with sarcopenia had lower values for skeletal muscle mass: FFMI [(17.68±0.74) vs. (18.34±0.54)kg/m2, F=33.696, P<0.05] and lower muscle function: HS [(17.26±4.20) vs. (28.85±6.43)kg, F=136.54, P<0.05], GS [(0.65±0.11) vs. (0.90±0.10)m/s, F=-12.922, P<0.05], SPPB [(6.45±2.07) vs. (7.65±1.76), t=-3.452, P<0.05]. And the cardiac function decreased significantly in patients with sarcopenia: 6-MWD [(253.76±72.62) vs. (340.91±55.78)m, F=54.350, P<0.05], LVEF [(39.12±7.02)vs. (43.83±5.81)%, t=16.060, P<0.05]. Serum IL-6/TNF-α/C1q levels were significantly elevated: IL-6[(14.12±1.40) vs. (13.46±1.06) ng/L, F=8.513, P<0.05], TNF-α [(443.43±28.06) vs. (299.37±21.53)ng/L, t=31.556, P<0.05], C1q[(578.92±23.63) vs. (504.11±41.77)ng/L, F=145.78, P<0.05]. Conclusion The CHF patients with sarcopenia present less skeletal muscle mass, poorer skeletal function and reduced cardiac function, and higher inflammation levels. Key words: Heart failure; Aged; Complement C1q; Sarcopenia
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Disclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.