Abstract
WhenHistoplasma capsulatum yeast cells were grown in the presence of partially inhibitory concentrations of saramycetin, electron microscopy revealed that the proportion of apparently damaged cells was a function of the concentration of the antibiotic. Evidence of early damage consisted of irregularity of outline, followed by progressive lysis of internal structures leading to residual dense granules, membranes, and the cell wall. Normal yeast cells of the strain studied were found to possess intranuclear bodies of a type apparently not previously described.
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