Abstract
Anxiety, the illness of our time, is one of the most prevalent and co-morbid psychiatric disorder that represents a significant socioeconomic burden. Conventional treatment is associated with a number of side effects and there is a need to develop new therapeutic strategies. Therefore, it is of interest to investigate the modulating effects of Salvia Officinalis L. and Rosmarinus Officinalis L. leaves extracts on anxiety using different behavioral tests, and on neural activity using the Multi-electrode array technique. Data shows the decrease of the time of the immobility associated with a significant increase in the time spent in the center of the open field arena in the treated animals compared to the controls. The number of buried marbles has also decreased in the treated animals in the marble-burying test. On the other hand results also show a decrease of the neural activity explained by a decrease of the number of spikes after 24,48 and 72 h following the addition of 12,5 µg/ml of the plant leaf extracts to the neural culture. However, there were no spikes after the administration of 25µg/ml of the plants extracts.
Highlights
Anxiety is a state of alertness, of psychological and somatic tension in response to an unpleasant feeling or anxiety-provoking situations
The open field test: Rosmarinus officinalis L. and Salvia Officinalis L. methanolic extracts reduce the time of immobility and increase the time spent in the center of the open field arena
It is of interest to investigate to investigate the modulating effect of Salvia Officinalis L. and Rosmarinus Officinalis L
Summary
Anxiety is a state of alertness, of psychological and somatic tension in response to an unpleasant feeling or anxiety-provoking situations. The occurrence of an unforeseen event, (not necessarily stressful); acts on the GABA receptors and decreases the regulatory influence, revealing the excitatory effects of adrenaline or serotonin This activates the limbic structures and induces a feeling of anxiety that stressors such as cortisol can accentuate [1]. Selective serotonin reuptake inhibitors (SSRIs) and serotonin and noradrenaline reuptake inhibitors (SNRIs) were considered the pharmacological treatment of choice [4, 5] These agents are not always effective against severe symptoms, do not work quickly and are often associated with side effects. Cognitive-behavioral psychotherapy promotes an active attitude toward treatment For these reasons, its therapeutic effects are more likely to last longer than those of pharmacotherapy [3]. The plants extracts are assessed for their ability to modulate the neural activity, using the multi electrode array technique on primary cortical culture
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