Abstract
ELEVATIONS of glutamic-oxaloacetic and glutamic-pyruvic transaminases have been reported to occur in sera from more than 50 per cent of children with rheumatic fever treated with either aspirin or sodium salicylate1. The injection of sodium salicylate in the rat caused an increased activity of xanthine dehydrogenase in the blood but a decreased activity of the enzyme in the liver, and it was suggested that the salicylate caused liver and other tissue damage leading to an increased rate of release of enzyme protein into the circulation2. We have therefore studied the effects of prolonged oral administration of salicylate on the activities of five plasma enzymes and on tissue histology in the rabbit.
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