Effect of sacral magnetic stimulation on the anorectal manometric activity: a new modality for examining sacro-rectoanal interaction

Abstract

We examined the interaction between the sacral neural system and the anorectal activity using a technique comprising repetitive magnetic stimulation. Thirteen control children without any bowel dysmotility (age range; 3 month old to 15 year old), 20 patients with chronic constipation (1 month old to 14 year old), and nine pre-operative patients with Hirschsprung's disease (1 month old to 6 year old) were examined. Magnetic stimulation was applied at the S3 level using the MagPro (Medtronic) device while simultaneously performing manometric recordings of the anorectal activity. In the 13 controls and the 20 patients with chronic constipation, the rectoanal reflex was demonstrated by balloon rectal dilatation. The sphincter response to magnetic stimulation was biphasic in the controls, consisting of an initial rise followed by a decrease in the sphincter pressure, while it varied among the patients with chronic constipation including a biphasic response in 16 patients, no response in three patients, and only a transient rise in pressure in one patient. In nine pre-operative patients with Hirschsprung's disease, no rectoanal reflex was observed, however, the sphincter pressure increased due to magnetic stimulation in six patients, while three patients exhibited no recordable responses. These results suggest that the repetitive magnetic stimulation technique is a valuable modality for investigating the neural interaction between the sacral nervous system and the anorectum.