Abstract
Recently, the antibacterial activity of a composite resin containing prereacted glass ionomer (S-PRG) filler was revealed. We examined the effect of an S-PRG eluate on various biologic activities of Streptococcus mutans and Porphyromonas gingivalis. Adherence ability of S. mutans was evaluated by microtiter plate assay; protease and gelatinase activities of P. gingivalis were examined by synthetic substrate hydrolysis and gelatin film spot assay, respectively. Coaggregation of P. gingivalis with Fusobacterium nucleatum was also examined. S-PRG eluate was found to suppress streptococcal adherence. S-PRG eluate inhibited the protease and gelatinase activities of P. gingivalis and the coaggregation between P. gingivalis and F. nucleatum. These results indicate that S-PRG eluate suppresses streptococcal adherence and inhibits the protease and coaggregation activities of P. gingivalis. These findings may prompt research into novel strategies for preventing caries and periodontitis.
Highlights
Dental caries and periodontitis are two major causes of tooth loss in adults
International Journal of Dentistry we report that an S-PRG eluate has a suppressive effect on adherence of S. mutans and on the proteolytic, gelatinase, and coaggregation activity of P. gingivalis
S-PRG fillers are widely used in many fields of dentistry, such as composite resins, cements, dentures, sealants, and so on [29], partly because of their ability to recharge with fluoride ions, the subsequent release of which promotes dentin remineralization
Summary
Dental caries and periodontitis are two major causes of tooth loss in adults. Dental caries arises from the interplay between the oral flora, teeth, and dietary factors. Sugar metabolism is central to the behavior of mutans streptococci, and sucrose, the most cariogenic dietary carbohydrate, is used to produce the extracellular polysaccharides that form the biofilm matrix, which facilitates the association of mutans streptococci with dental plaque. P. gingivalis has several biologic activities such as protease secretion and coaggregation [6, 7]. Gingipain is associated with gelatinase activity [11], which may cause periodontal tissue degradation. P. gingivalis coaggregates with other oral bacteria such as Fusobacterium nucleatum, and the formation of these multistrain complex communities is an initial and critical step in the pathogenesis of periodontitis [12]
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