Abstract
Summary1. When sodium P32-phosphate was injected intravenously into calves, there was an early labeling of leukocyte DNA. 2. DCVC decreased but did not abolish this uptake of P32 when given concurrently with P32 or when calves were pre-treated with DCVC for 2 or 4 days. 3. When normal calf blood was incubated in presence of H3-thymidine, there was a rapid nuclear uptake by mononuclear leukocytes. 4. DCVC did not inhibit incorporation of H3-thymidine in either blood from DCVC-treated calves or in normal blood incubated in presence of DCVC. 5. Abolishment of DNA synthesis in leukocytes or leukopoietic tissue does not appear to be a primary biochemical lesion through which DCVC induces fatal blood dyscrasia in calves.
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Schedule a callMore From: Proceedings of the Society for Experimental Biology and Medicine. Society for Experimental Biology and Medicine (New York, N.Y.)
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