Abstract
Rutin, a phenolic compound found in many plants is known to have anti-oxidative and anti-inflammatory properties. It has been reported that rutin rescues the cells from the challenges such as ethanol, methylmercury, radiation, hydrogen peroxide, and other cytotoxic chemicals. It is also suggested to enhance mitochondrial biogenesis in obese rats.Cytochrome c oxidase is a rate limiting enzyme in mitochondrial electron transport chain and consequently influences on mitochondrial membrane potential and therefore the ATP production. Also its electron donor cytochrome c is well known to participate in type 2 apoptosis in cells.Here it is shown that rutin elevates the activity of cytochrome c oxidase in human breast cancer cells. The mitochondrial respiration and cellular energy levels also increase by rutin treatment. We propose that the beneficial cytoprotective effects of rutin might due to, at least in part, the upregulated mitochondrial enzyme, cytochrome c oxidase which would enhance mitochondrial respiration and therefore cellular energy levels.∗This research was supported by Basic Science Research Program through the National Research Foundation of Korea(NRF) funded by the Ministry of Education(NRF-2014R1A1A2058722).
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