Abstract
RU 41740, a glyco-protein extract of Klebsiella pneumoniae 01 K2 strain, is known to have immunomodulator activities. It acts on macrophages as well as on B and T-cells, and enhances their cytokine production, particularly interleukin 1(IL-1). The fact that cytokines have an effect on hemopoiesis led us to suspect an effect of RU 41740 on hemopoietic reconstitution. In this study, a model of autologous reconstitution of a hemopoietic system after sublethal irradiation in mice was used. C57 BL/6 mice were treated orally with RU 41740 (10 mg/kg/day) before or after irradiation (6.5 Gy). LPS of Klebsiella pneumoniae was used as a positive control. The hemopoietic reconstitution occurred more rapidly in treated animals especially when RU 41740 was given before irradiation.
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