Abstract
Cardiovascular diseases are one of the most common complications of type 2 diabetes. They are considered the leading cause of death among diabetics. One of the mechanisms underlying diabetic cardiovascular complications is oxidative stress. Many phenolic acids are regarded as antioxidants. The aim of the study was to investigate the effect of rosmarinic acid (RA) and sinapic acid (SA) on oxidative stress parameters in the cardiac tissue and serum of type 2 diabetic female rats. Additionally, the effect of these compounds on glucose homeostasis and lipid profile in the serum was evaluated. Type 2 diabetes was induced with high-fat diet and streptozotocin. RA at the doses of 10 and 50 mg/kg and SA at the doses of 5 and 25 mg/kg were administrated orally for 28 days. Untreated diabetic rats exhibited unfavorable changes in glucose metabolism and lipid profile. Changes in the enzymatic and non-enzymatic markers indicated the onset of oxidative stress in these animals. The results showed that the higher doses of the tested phenolic acids—50 mg/kg of RA and 25 mg/kg of SA—revealed beneficial effects on oxidative stress in the cardiac tissue of diabetic rats.
Highlights
IntroductionAs of 2017, there were 425 million diagnosed diabetics worldwide, and this number may increase up to 629 million in 2045 according to an International Diabetes Federation report [2]
Diabetes mellitus (DM) poses a serious public health issue [1]
The results presented as mean ± SEM were evaluated by one-way ANOVA followed by Least Significant Difference (LSD) post-hoc test
Summary
As of 2017, there were 425 million diagnosed diabetics worldwide, and this number may increase up to 629 million in 2045 according to an International Diabetes Federation report [2]. Type 2 diabetes, which is characterized by hyperglycemia, insulin resistance, and disturbance in lipid, protein, and carbohydrate metabolism, is the most often diagnosed type in adults Of adult diabetics) [3,4,5,6]. A range of diabetic complications may develop, namely diabetic cardiomyopathy, myocardial insufficiency, retinopathy, nephropathy, neuropathy, and hyperlipidemia [5,7,8]. The cardiovascular complications of diabetes are considered the major factor resulting in deaths of diabetic patients [3,7,9,10]
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