Abstract
Rifampicin LEPETIT, an antibiotic known to interfere with the activity of DNA-dependent bacterial RNA polymerase, prevented the conjugational transfer of R-factors in Salmonella typhimurium and Escherichia coli, and showed appreciable accumulation of R— variants in R+ cultures. The drug was active in concentrations from 0.25 to 5.0 μg/ml while there was no influence on the viable count of the R+ cultures. Although the concentrations of rifampicin found to be active in R+ strains of enterobacteria are about 10 times higher than those found to be active in staphylococci by JOHNSTON and RICHMOND (1970), the sub-bacteriostatic concentrations of the drug were effective enough to eliminate R-factors and to prevent their transfer from the donor cells studied.
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