Effect of Resveratrol on Oxidative Stress Enzymes in Rats Subjected to 70% Partial Hepatectomy

Abstract

This experimental study investigated the antioxidant status of rats after resveratrol (R) treatment following 70% partial hepatectomy. Thirty Wistar albino rats (200 to 250 g) were devided among: groups A and B ( n = 10 each) underwent laparotomy and 70% partial hepatectomy (PH). Whereas rats in group A received resveratrol 60 mg/d per nasogastric tube for 7 days before and 3 days after PH (PH + R), those in group B underwent PH only. Rats in group C ( n = 10) were subjected to a sham operation. Significant increases in tissue levels of reduced glutathione (GSH) and decreased malondialdehyde (MDA) levels were observed in the PH group receiving R compared with those of the PH group ( P < .001 for all). Comparison of these parameters with those of the sham group revealed significantly higher tissue levels of GSH and lower MDA levels among sham-operated compared with PH + R and PH groups ( P < .001 for all). Concerning the NO levels, a trend to a slightly decrease was observed in the PH + R group ( P < .06). Interleukin-6 levels showed significant decreases in both PH + R and PH groups ( P < .001 and P < .05, respectively). The tissue GSH levels were slightly decreased in PH + R ( P < .05), and decreased in the PH group compared with the controls ( P = .002). We have suggested that patients undergoing living donor liver transplantation would likely benefit from prophylactic treatment with foods having resveratrol.