Abstract
We investigated the protective effects of resveratrol on hematological and biochemical changes induced by fluoride in rats. A total of 28 rats were divided into 4 groups: control, resveratrol, fluoride, and fluoride/resveratrol (n = 7 each), for a total of 21 days of treatment. Blood samples were taken and hematological and biochemical parameters were measured. Compared to the control group, the fluoride-treated group showed significant differences in several hematological parameters, including decreases in WBC, RBC, and PLT counts and neutrophil ratio. The group that received resveratrol alone showed a decrease in WBC count compared to the control group. Furthermore, in comparison to the control group, the fluoride group showed significantly increased ALT enzyme activity and decreased inorganic phosphorus level. The hematological and biochemical parameters in the fluoride + resveratrol treated group were similar to control group. In the fluoride + resveratrol group, resveratrol restored the changes observed following fluoride treatment, including decreased counts of WBC, RBC, and PLT, decreased neutrophil ratio and inorganic phosphorus levels, and elevated ALT enzyme activity. The present study showed that fluoride caused adverse effects in rats and that resveratrol reduced hematological and biochemical alterations produced by fluoride exposure.
Highlights
Fluoride is an essential element [1] but one that can cause serious health problems when drinking water contains fluoride at a concentration greater than 1 ppm or in the regions where a large amount of fluoride is released due to the burning of fluoride-loaded coal [2, 3]
The present study investigated the protective effects of resveratrol, a potent antioxidant, on fluoride-induced alterations in hematological and biochemical parameters of the blood, which is a target tissue for fluoride toxicity
In the fluoride plus resveratrol group, resveratrol alleviated the adverse effects on White blood cells (WBC), red blood cells (RBC), and platelet count (PLT) counts and neutrophil ratio caused by fluoride
Summary
Fluoride is an essential element [1] but one that can cause serious health problems when drinking water contains fluoride at a concentration greater than 1 ppm or in the regions where a large amount of fluoride is released due to the burning of fluoride-loaded coal [2, 3]. Fluoride causes adverse effects in soft tissues such as blood, brain, and liver [4] by passing through the cell membrane [5]. It has been reported that changes due to fluoride exposure occur earlier in blood compared to other tissues and organs [8]. No previous study exists on the potential of resveratrol to alleviate or eliminate adverse effects produced by fluoride exposure in rats. The present study investigated the protective effects of resveratrol, a potent antioxidant, on fluoride-induced alterations in hematological and biochemical parameters of the blood, which is a target tissue for fluoride toxicity.
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