Abstract
Objectives: Abnormal rheological properties induce adverse effects during sepsis. This study sought to investigate the hypothesis that resveratrol (Res) improves blood rheological properties in rats following a lipopolysaccharide (LPS) challenge, and provide a novel approach for treatment of sepsis.Methods: The rats were intraperitoneally or intramuscularly injected with vehicle, LPS (8 mg/kg), Res (30 mg/kg), or both to yield four groups: control, Res, LPS, and LPS + Res. After 6 h of LPS and/or Res injection, the mean arterial pressure (MAP), regional blood flow, erythrocyte and leukocyte parameters, and blood viscosity were observed.Results: LPS administration had no significant effects on the erythrocyte parameters and plasma viscosity. LPS administration reduced the MAP, whole blood viscosity at low and medium shear rates, the blood flow in the spleen and kidney, and the leukocyte content in whole blood when compared to control group, and increased the myeloperoxidase (MPO) activity in lung. Treatment with Res alone had no effects on most of parameters observed except increasing the whole blood relative viscosity. However, Res treatment after LPS resulted in further decrease in whole blood viscosity at high and medium shear rates. Furthermore, Res treatment conversely decreased the red blood cell distribution width-CV, blood flow of stomach, whole blood relative viscosity and MPO activity in lung, and increased the leukocyte content, but did not restore LPS-induced decrease in MAP and the blood flow in the spleen and kidney.Conclusion: The Res treatment partly reduce the whole blood viscosity and regional blood flow, and increase WBC content in peripheral blood following the LPS challenge, suggesting a favorable role in expanding the quasi-sympathetic effects of LPS in blood viscosity at early stages.
Highlights
Sepsis induced by peritonitis is a common but critical pathological process (Ge et al, 2016)
Res on LPS-Induced Abnormal Rheology or post-administration of resveratrol (Res) could alleviate organ injury in animal models of endotoxic shock or sepsis induced by cecal ligation and puncture (Kolgazi et al, 2006), or administration of lipopolysaccharide (LPS) by either intravenous injection (Sebai et al, 2011), intraperitoneal injection (Zhao et al, 2014), or airway instilment (Knobloch et al, 2011)
The Res treatment has no effect on the mean artery pressure (MAP) and did not restore the decreased MAP in the rats following the LPS injection (P > 0.05, Figure 1)
Summary
Sepsis induced by peritonitis is a common but critical pathological process (Ge et al, 2016). Res on LPS-Induced Abnormal Rheology or post-administration of resveratrol (Res) could alleviate organ injury in animal models of endotoxic shock or sepsis induced by cecal ligation and puncture (Kolgazi et al, 2006), or administration of lipopolysaccharide (LPS) by either intravenous injection (Sebai et al, 2011), intraperitoneal injection (Zhao et al, 2014), or airway instilment (Knobloch et al, 2011). These beneficial effects of Res treatment are associated with anti-inflammatory response and relief from oxidative stress. The aim of the current study was to observe the effect of Res on blood rheological properties in rats following an LPS challenge via intraperitoneal injection
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