Effect of Resveratrol, a Dietary-Derived Polyphenol, on the Oxidative Stress and Polyol Pathway in the Lens of Rats with Streptozotocin-Induced Diabetes.

Lech Sedlak,Weronika Wojnar,Ilona Kaczmarczyk-Sedlak,Ewa Mrukwa-Kominek,Dorota Wyględowska-Promieńska,Maria Zych

doi:10.3390/nu10101423

Lech Sedlak, Weronika Wojnar + Show 4 more

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https://doi.org/10.3390/nu10101423

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Journal: Nutrients	Publication Date: Oct 4, 2018
Citations: 37	License type: CC BY 4.0

Affiliation: Medical University of Silesia, University of Silesia

Abstract

Resveratrol is found in grapes, apples, blueberries, mulberries, peanuts, pistachios, plums and red wine. Resveratrol has been shown to possess antioxidative activity and a variety of preventive effects in models of many diseases. The aim of the study was to investigate if this substance may counteract the oxidative stress and polyol pathway in the lens of diabetic rats. The study was conducted on the rats with streptozotocin-induced type 1 diabetes. After the administration of resveratrol (10 and 20 mg/kg po for 4 weeks), the oxidative stress markers in the lens were evaluated: activity of superoxide dismutase, catalase and glutathione peroxidase, as well as levels of total and soluble protein, level of glutathione, vitamin C, calcium, sulfhydryl group, advanced oxidation protein products, malonyldialdehyde, Total Oxidant Status and Total Antioxidant Reactivity. The obtained results indicate that the administration of resveratrol to the diabetic rats shows antioxidative properties. It is not a result of antiglycaemic activity but resveratrol probably directly affects the antioxidative system. Resveratrol did not affect the polyol pathway in the lens of diabetic rats. Our results may indirectly indicate benefits of consumption of foods as well as dietary supplements containing resveratrol in diminishing oxidative stress in lenses of individuals suffering from diabetes mellitus.

Highlights

Resveratrol (3,40,5-trihydroxy-stilbene) is a polyphenolic compound discovered in 1939
Results are presented as means ± SEM (n = 8–9). * p < 0.05—statistically diabetic rats receiving resveratrol
No statistically significant changes between the D+R10 and D+R20 group in the all parameters wereDiabetes reported.mellitus (DM) is a disease characterized by chronic hyperglycaemia and disturbances of carbohydrate, fat and protein metabolism resulting from an absolute or relative deficiency of

Summary

Introduction

Resveratrol (3,40 ,5-trihydroxy-stilbene) is a polyphenolic compound discovered in 1939. O.Loes.—the plant in which roots resveratrol was found for the first time. Resveratrol occurs in many plants such as apples, blueberries, mulberries, peanuts, pistachios, plums, raspberries and soy. The highest concentrations of this stilbene were found in the dried roots and rhizomes of Japanese knotweed—Reynoutria japonica Houtt. Synonyms Fallopia japonica (Houtt.) Ronse Decr., Polygonum cuspidatum Siebold & Zucc.—which are used in a form of tea in Traditional Chinese. In Europe, its main sources are dark varieties of grapes (Vitis vinifera L.) and red wines, Nutrients 2018, 10, 1423; doi:10.3390/nu10101423 www.mdpi.com/journal/nutrients. Nutrients 2018, 10, 1423 containing roughly 3- to 10-fold more resveratrol than white grape varieties or white wines. Resveratrol can be synthesized in larger amounts by plants in response to pathogens and abiotic stress [1]

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