Effect of respiratory viruses infection for pediatric asthma exacerbations and outcome of therapy in children with asthma

Abstract

Objective To analyze whether respiratory virus participated in the pediatric asthma exacerbations and their impact on the treatment response. Methods The 488 children with acute asthma were chosed as the research object, and divided into mild, moderate and severe degree respectively depending on its severity.The tests for pathogen includes respiratory syncytial virus (RSV), rhinovirus (HRV), parainfluenza virus (PIV), influenza virus (IVB), adenovirus and Mycoplasma pneumoniae and to analyze their relationship with acute asthma attacks and therapeutic effect. Results RSV-B and PIV infection was associated with moderate to severe asthma (adjusted 95% confidence interval was -22.94% to 4.25% and -44.47% to -18.93%, respectively). Virus infection was associated with poor treatment in children with acute asthma (95% confidence interval: 3.33% to 13.15%), including RSV, HRV and PIV were strongly associated with poor treatment (95% confidence interval: 14.14% to 28.71%, 17.88% to 57.23% and 20.4% to 73.0%). There was no correlation between rhinovirus infection and poor treatment. Conclusions RSV-B and PIV infection are associated with moderate to severe asthma.Respiratory virus infection, especially RSV, HRV and PIV interfere with asthma treatment. Key words: Asthma, childhood; Virus infection, respiratory; Syncytial virus; Rhinovirus