Abstract
Resolvins, are specialized pro-resolving mediators (SPMs) derived from n-3 polyunsaturated fatty acids. They contribute actively to the resolution of inflammation, but little is known concerning their role in chronic inflammation, such as in rheumatoid arthritis (RA). Here, we performed lipid mediator (LM) profiling in tissues from the paws of SKG arthritic mice using lipid chromatography (LC)/mass spectrometry (MS)/MS-based LM metabololipidomics. We found elevated levels of SPMs including resolvin D5 (RvD5) in these tissues. Moreover, RvD5 levels were significantly correlated with arthritis disease activity. From experiments to assess the role of RvD5 in the pathology of RA, we concluded that RvD5 suppressed Th17 cell differentiation and facilitated regulatory T cell differentiation, as well as inhibiting CD4+ T cell proliferation. Furthermore, RvD5 attenuated osteoclast differentiation and interfered with osteoclastogenesis. Targeting the resolution of inflammation could be promising as a novel treatment for RA.
Highlights
Resolvins, are specialized pro-resolving mediators (SPMs) derived from n-3 polyunsaturated fatty acids
On day 56, there was a strong trend for correlation between levels of resolvin D5 (RvD5) and arthritis score (r = 0.681, P = 0.063) (Fig. S1). These results suggested that RvD5 might be involved in the pathogenesis of arthritis
Further investigations are required to determine the effect of SPM on chronic arthritis and to determine cell targets in rheumatoid arthritis (RA) pathogenesis
Summary
Resolvins, are specialized pro-resolving mediators (SPMs) derived from n-3 polyunsaturated fatty acids. They contribute actively to the resolution of inflammation, but little is known concerning their role in chronic inflammation, such as in rheumatoid arthritis (RA). Over the last two decades, it has become increasingly clear that resolution of acute inflammation is not a passive process, but requires active modulation[1,2] This is tightly regulated by families of novel potent bioactive LMs, which have been termed “specialized pro-resolving mediators” (SPMs)[3,4]. RA is a chronic inflammatory disease characterized by synovial inflammation and hyperplasia, autoantibody production, and bone destruction[6]. Few reports have examined the role of other SPMs in immune cells and their involvement in inflammatory diseases
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