Abstract
The effect of resistance training and a herbal supplement on muscular signaling pathways are limited. We investigated the expression of IL-6, Gp130, JAK and STAT after resistance training, and Spirulina platensis supplementation in animal muscle. Thirty-two male Sprague Dawley rats (weight: 290 ± 20 g, and 9 weeks of age) were divided into four groups: control (CO; n = 8), Spirulina platensis supplementation (SP; n = 8), resistance exercise (RE; n = 8), and Spirulina platensis + resistance exercise (SP + RE; n = 8). The resistance exercise group trained five sessions each week for eight weeks. Spirulina 200 mg kg−1 d−1 was used in the SP and SP + RE groups. Gene expression was measured by real-time PCR following the last training session. One-way ANOVA test with Tukey’s post-hoc test were used for analysis of data (SPSS, version, 21). Data analysis revealed that the expression of IL-6 (P = 0.001), Gp130 (P = 0.001), JAK (P = 0.0001) and STAT (P = 0.004) increased significantly in the RE group. The expression of IL-6 (P = 0.018), JAK (P = 0.001) and STAT (P = 0.001) in SP + RE group also increased significantly (P ≤ 0.05). SP showed a significant increase in Gp130 (P = 0.001) and STAT (P = 0.001). Supplementation by Spirulina platensis may enhance muscle accretion during resistance training.
Highlights
IntroductionThe vital importance of skeletal muscle for general health and in the performance of daily activities is well established
Data analysis revealed that the expression of Interleukin 6 (IL-6) in resistance exercise (RE) (P = 0.016) and SP + RE (P = 0.018) groups were significantly increased compared to CO (RE: 2.808 ± 0.66 (63.9%); and RE + SP: 2.462 ± 0.54 (58.9%) vs. CO: 1.011 ± 0.15)
The data showed that the levels of interleukin IL-6, glycoprotein 130 (Gp130) and JAK-signal Janus kinase and transcription activator (STAT) in RE and RE + SP were significantly higher after the intervention period compared to CO
Summary
The vital importance of skeletal muscle for general health and in the performance of daily activities is well established. Skeletal muscle has several functions, including protection of vital organs, movement and meeting the metabolic demands of exercise [1]. Maintaining or even increasing skeletal muscle mass is important for many athletes and in many other conditions, including the elderly, and, diseases associated with muscle atrophy (such as cancer, AIDS, and diabetes) [2]. Great efforts have been made to clarify the cellular and molecular mechanisms of both muscle hypertrophy and atrophy. It is possible that identifying regulators or signals and understanding how they work will open up new avenues for the development of treatment for pathologies and exercise programs.
Sign-in/Register to view highlights & summary Sign-in/Register to access full text options 
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callDisclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
