Abstract
The purpose of this study were to evaluate the residual volume of radiopharmaceuticals in the three-way stopper and syringe used during radiopharmaceutical administration and the effect of washing. The three-way stoppers were a top injector tube, a top three-way stopper, and a Nipro three-way stopper with a needle. Sodium pertechnetate [99mTc] injection (99mTcO4-) was used to compare the residual volume of radiopharmaceuticals in the three-way stopper and syringe without and with washing. Clinically, 137 patients who underwent cerebral blood flow scintigraphy, dopamine transporter scintigraphy, and bone scintigraphy were included. N-isopropyl-p-[123I]iodoamphetamine (123I-IMP), 123I-N-ω-fluoropropyl-2β-carboxymethoxy-3β-(4-iodophenyl)nortropane (123I-FP-CIT), and 99mTc-methylene diphosphonate (99mTc-MDP) were used to compare the residual volume of radiopharmaceuticals in the three-way stopper and syringe without and with washing. The residual volume depended on the type of three-way stopper and radiopharmaceutical used. The residual volume could be reduced by washing, but the effect depended on the type of three-way stopper and radiopharmaceutical used. The residual volume of radiopharmaceuticals in three-way stoppers and syringes can be determined and subtracted to achieve more accurate dose control.
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