Abstract
Effect of fenvalerate on residual concentration, cell architecture and biochemical parameters of tissue following dermal application at 0.1% in ethanol three times per week for a period of 150 days in cockerels was studied. Brain contained the maximal residue followed by heart, omental fat, liver and kidney in sequence. It increased the AST activity in kidney and heart, ALT activity in liver, kidney, heart and brain; AP activity in liver, kidney and heart tissues. It decreased the AST activity in brain; and acetyl cholinesterase activity in liver and brain tissues. In conclusion, it appears that chronic dermal application of fenvalerate for 150 days does not produce any clinical signs of toxicity. It produced proliferation of bile duct, periportal fibrosis, aggregation of mononuclear cells resembling lymphoctyic nodule in liver; hypertrophy of glomeruli, thickening of Bowman's capsule, fibrosis and accumulation of mononuclear cells in between the kidney tubules; fatty degeneration of heart tissue and cong...
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