Abstract
The present study was aimed to appraise the oxidative stress potential of bifenthrin in heart homogenates in wistar rats after its repeated dermal application for a period of 30 days. The rats were divided into four groups with six rats in each group. Group I and III served as control and were applied with distilled water @ 1.8ml/Kg/day whereas the animals of group II and IV were dermally applied with bifenthrin @ 45mg/Kg/day for 20 and 30 days respectively. Significant increase in MDA level was observed in heart homogenate after 20th and 30th day of dermal treatment. Significant decrease in SOD was observed both after 20th and 30th days of dermal treatment. GSH-Px increased significantly after 20th and decreased significantly after 30th day of treatment. The concentration of GST increased significantly both after 20th and 30th days of dermal application. However, no significant change was observed in CAT activity even after 30th day of dermal treatment.
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