Abstract
Effects of renovascular hypertension (RVH) on the cardiac and coronary response to exercise was examined in seven (7) dogs chronically instrumented to measure left ventricular systolic pressure (LVSP), mean arterial pressure (MAP), +dP/dtmax, heart rate (HR), cardiac output (CO), coronary blood flow (CBF) and myocardial oxygen consumption (MVO2). Data were collected at rest and during submaximal exercise, before (normotensive, NT) and after development of RVH produced by unilateral renal artery stenosis. Cardiac data are shown in the table:TableThe slope of the relationships between +dP/dtmax, CO and CBF versus MVO2 were significantly decreased after RVH. These data indicate that RVH attenuates the ability to increase myocardial contractile function in response to sympathetic stimulation during exercise. This could be due to coronary hypoperfusion, altered left ventricular β-receptor response to sympathetic stimulation, functional and/or metabolic changes in the left ventricle. (Funded by HL59405)
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