Abstract
To investigate the effect of renal denervation (RDN) on the blood pressure, left ventricular hypertrophy and myocardial expression of TLR4/NF-κB in spontaneously hypertensive rats (SHR). A total of 36 SHR were randomly assigned into control group (D0), RDN group (D) and sham group (S). 12 WKY rats of same age served as controls (WKY group). Rats in the D0 and WKY groups were sacrificed, but rats in the D and S group were sacrificed at one week and six weeks after surgery. The heart was collected and the left ventricle weighted followed by calculation of left ventricular mass index (LVMI). In the D0 group, the blood pressure, LVMI and protein expression of TLR4, NF-κB, TNF-α and IL-6 in the myocardium were markedly higher than that in the WKY group (p<0.05). In the D1 and D2 group, the LVMI, NE and protein expression of TLR4, NF-κB, TNF-α and IL-6 in the myocardium were significantly reduced (p<0.05). Renal denervation can significantly delay the progression of left ventricular hypertrophy in spontaneously hypertensive rats, which may be attributed to the not only the suppression of sympathetic activity and attenuation of pressure load but the improvement of myocardial immuno-inflammation.
Highlights
Left ventricular hypertrophy (LVH) is one of common consequence of hypertension and studies have demonstrated that hyperactivity of sympathetic nervous system and immune/ inflammatory response play important role in the occurrence and development of LVH1,2
Renal denervation (RDN) was done in spontaneously hypertensive rats (SHR) and the blood pressure, left ventricular mass index (LVMI) and expression of TLR4, NF-κB, TNF-α and IL-6 in the myocardium were determined before and after renal denervation (RDN) and the potential mechanism underlying the protective effect of RDN on LVH was explored
RDN was performed in SHRs and results showed the blood pressure and LVMI reduced significantly at one week after surgery, At one week after surgery, the NE in the kidney was markedly reduced as compared to the control group, suggesting complete dennervation, which was consistent with findings of Krum et al.[6]
Summary
Left ventricular hypertrophy (LVH) is one of common consequence of hypertension and studies have demonstrated that hyperactivity of sympathetic nervous system and immune/ inflammatory response play important role in the occurrence and development of LVH1,2. Krum et al.[6] performed percutaneous renal artery ablation in the treatment of refractory hypertension Their results showed the reduction of blood pressure was usually accompanied by the decrease in left ventricle mass. This suggests renal denervation can delay or even reverse the hypertension induced target organ damage, but the specific mechanism is still poorly understood. Renal denervation (RDN) was done in spontaneously hypertensive rats (SHR) and the blood pressure, left ventricular mass index (LVMI) and expression of TLR4, NF-κB, TNF-α and IL-6 in the myocardium were determined before and after RDN and the potential mechanism underlying the protective effect of RDN on LVH was explored
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