Abstract
Groups of unshielded and regionally shielded rats were exposed to 800 R X-irradiation and compared with nonirradiated controls. As reported in an earlier study , unshielded rats showed a moderate rise in plasma glutamic oxalacetic transaminase (PGOT) at 6 hr and a marked fall in plasma alkaline phosphatase (PAkP) at 4 days after irradiation. Shielding the abdomen prevented or greatly lessened these changes. Irradiating only the abdomen produced a relatively moderate rise in PGOT at 6 hr but caused a marked fall in PAkP at 4 days after irradiation comparable to that found after whole-body X-irradiation. It is suggested that the rise in PGOT is derived in part from excess GOT released from overtly damaged lymphoid and other radiosensitive tissues and in part from other tissues due to a wide-spread initial increase in cellular permeability induced by X-irradiation. The fall in PAkP is attributed to a reduced contribution of intestinal AkP to the circulation due to radiation injury to the intestinal mucosa.
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