Abstract
Megakaryocytes are found in the intact rat spleen in various forms: with a ring-shaped nucleus and as large multinuclear cells. The megakaryocytes divide by the formation of multipolar mitoses without subsequent cytotomy. During regeneration the number of megakaryocytes and their mitotic activity increased sharply. Gravitational overloading increased the number of megakaryocytes and their mitotic activity even more. Administration of splenic extract in addition to gravitational overloading reduced the number of megakaryocytes in the regenerating spleen but increased their mitotic activity. Under conditions of hypokinesia the number of megakaryocytes in the regenerating spleen fell sharply and no mitoses were observed in them.
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