EFFECT OF REDUCING RENAL ARTERIAL BLOOD PRESSURE BY BALLOON CATHETER ON URATE EXCRETION IN THE DOG.

Abstract

SummaryReduction of mean renal arterial blood pressure of Dalmatian and mongrel dogs by inflating a balloon-tipped catheter inserted into the aorta just above the renal arteries resulted in a proportionate decrease in GFR, less decrease in CPAH, a precipitous fall in UNaV/FNa, no appreciable change in UKV/FK. In the Dalmatian, under conditions of net secretion of urate, UurateV/Furate was unchanged or rose somewhat. A comparable response of UurateV/Furate was obtained in mongrels under conditions of net reabsorption of urate, a result consistent with tubular secretion of urate masked by preponderant tubular reabsorption.