Abstract
The amount of oxygen delivered to the oxygen-consuming mitochondria within a tissue is critically dependent on the oxygen tension gradient between the capillary lumen and the tissue. Leftward shift of oxygen binding curve decreases the magnitude of this gradient. In our patients total oxygen supply was not compromised sufficiently to enable us to demonstrate any actual disadvantage caused by the decreased p50act, however we found an unsafe drop in PvO2, below 32 mmHg, in 13 patients. p50act has a strong correlation with mixed venous pH and pCO2. The maintenance of a mild acidosis and hypercapnia could prevent unsafe drops in PvO2 values.
Sign-in/Register to access full text options 
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callDisclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
